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Statistical validation of the brief International Classification of Functioning, Disability and Health Core Set for osteoarthritis based on a large international sample of patients with osteoarthritis


Oberhauser, Cornelia; Escorpizo, Reuben; Boonen, Annelies; Stucki, Gerold; Cieza, Alarcos


American College of Rheumatology


Arthritis Care and Research, 2013, Volume 65 (Number 2), Seite 177-186, Hoboken, New Jersey: Wiley, ISSN: 2151-464X (Print); 2151-4658 (Online)





With the International Classification of Functioning, Disability and Health (ICF), the impact of health conditions on functioning and disability can be described. A Comprehensive and Brief ICF Core Set for osteoarthritis (OA) were developed. Our specific aims were to validate the Brief ICF Core Set for OA using a novel approach, i.e. to identify ICF categories that best explain patients' functioning, and to propose a statistically-validated version.


Psychometric study using Group Lasso regression on data from a convenience sample of 879 OA patients from 20 countries. The subscale on general health of the SF-36 was used as dependent variable and all ICF categories of the Comprehensive ICF Core Set for OA and some socio-demographics and disease-specific characteristics as independent variables. The most relevant ICF categories were identified as those showing a significant effect based on the pointwise 90% confidence intervals resulting from 1000 bootstrap trials.


The set of ICF categories that best explains patients' functioning consists of four body functions, two body structures, two activities and participation and three environmental factors. Twelve of the original 13 Brief ICF Core Set categories were confirmed, and three additional ICF categories were identified.


Our findings reassure the validity of the Brief ICF Core Set for OA. The statistically validated Core Set with the additional statistically-derived ICF categories will likely perform better with regard to discrimination and sensitivity to change in studies and trials, and should be further explored in the future.

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Zeitschriftenbeitrag / Forschungsergebnis


Arthritis Care & Research

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Informationsstand: 06.07.2012

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