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Effectiveness of rehabilitation intervention in persons with multiple sclerosis: A randomised controlled trial


Autor/in:

Khan, Fary; Pallant, Julie F.; Brand, C.; Kilpatrick, T. J.


Herausgeber/in:

British Medical Association


Quelle:

Journal of Neurology, Neurosurgery, and Psychiatry, 2008, Volume 79 (Number 11), Seite 1230-1235, London: BMJ British Publishing Group, ISSN: 0022-3050 (Print); 1468-330X (Online)


Jahr:

2008



Link(s):


Ganzen Text lesen (PDF | 183 KB)


Abstract:


Objective:

A stratified, randomised, waitlist controlled study over 12 months assessed the effectiveness of rehabilitation in persons with multiple sclerosis (MS) in an Australian community cohort.

Methods:

Patients with definite MS (n=101) recruited from a tertiary hospital database, randomised to a treatment group (n=49) for individualised rehabilitation programme or a control waitlist group (n=52). Functional Independence Measure (FIM) was used to assess ‘‘activity'' while the Multiple Sclerosis Impact Scale (MSIS-29) and General Health Questionnaire (GHQ-28) assessed ‘‘participation'' and quality of life (QoL). Assessments were at baseline and 12 months.

Results:

Analysis of data from 98 patients (treatment n=48, control n=50) showed reduced disability in the treatment group, with statistically significant differences in post-treatment FIM motor scores for the two groups (p,0.001).
There was a clinical and statistically significant improvement in FIM (motor) total scores (p,0.001), and the FIM motor domains of: transfer (p,0.001), locomotion (p,0.001), self-care (p,0.001) and the FIM cognitive subscale (p,0.016). In the treated group, 70.8% improved compared with 13% of controls. Significantly more patients in the control group deteriorated over the study period (58.7% vs 16.7%; p,0.001). There were no differences between the control and treatment group scores on the MSIS-physical (p=0.18), MSIS-psychological (p=0.45) or GHQ subscales.

Conclusion:

An individualised rehabilitation programme reduces disability in persons with MS compared with no intervention. The impact of rehabilitation on QoL needs
further evaluation. More information on the effectiveness of the various components of the multidisciplinary rehabilitation programmes are now needed.


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Dokumentart:


Zeitschriftenbeitrag / Forschungsergebnis / Online-Publikation




Bezugsmöglichkeit:


Journal of Neurology, Neurosurgery, and Psychiatry
Homepage: https://jnnp.bmj.com/

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Referenznummer:

R/ZA4496


Informationsstand: 03.05.2010

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